Does Promethease Provide Ancestry Information?

The simple answer to this question is: no.


Promethease, as a platform, does not provide information on genetic ancestry. Promethease is a literature retrieval system -- it compares genetic variants within your genetic data from a raw data file to the findings from actual scientific publications.


Using Promethease.com, you can find medical conditions you may be at risk for and other health information related to SNPs in your genome. Though the system is not designed to find ancestry information, it can be used to research medical conditions and your genetic health.


What Can Promethease Be Used For?

Promethease is a platform which allows you to do DNA research on your own. Using the platform you can search for different conditions, edit the number of studies required for results to show up, and even research specific SNPs. Using your DNA data, Promethease analyzes which SNP variants you carry, and directs you to studies which have covered those variants and their effects.


Promethease can also be used to analyze multiple samples at once, and compare the raw DNA data between the samples. The platform has a number of various tools to filter the results which allow users to analyze the genetic variants of their choice. However, Promethease can also be very confusing, and any health reports you obtain should be reviewed with a genetic counselor. One option searches for clinvar information, which are genes which have been clinically verified to be associated with specific conditions. These genetic variants may put you at high risk for certain conditions.


If you’re new to Promethease and want to take a crack at it, follow this guide on how best to extract the most important and relevant information to you.


Promethease Haplogroup Research

However, there is a longer answer to the initial question.


Promethease does have some tools which allow you to track your haplotype. The haplogroup you belong to can be identified within genes found on mitochondrial DNA (mtDNA), X-chromosomes, and Y-chromosomes. The problem is not all genetic testing companies test mtDNA, X-DNA, or Y-DNA. Many companies focus only on autosomal DNA, which does not carry haplogroup information.


The Promethease platform does allow the ability to analyze for haplotype if you used the right genetic testing company. For example, users on the Ancestry Support Page reported that AncestryDNA, MyHeritage, and FamilyTreeDNA kits do not test for the specific SNPs required to determine haplogroup, while 23andMe does test segments of the mtDNA and Y-chromosome.


Getting a Promethease report on your ancient family history is no simple feat, unfortunately. Using their analysis tool, a number of steps are required to determine your haplotype. Various sites cover this process, including a site from SNPedia covering haplogroups and an ISOGG page covering SNPs related to various haplogroups.


Other Ways to Get Ancestry Information

If you are working on becoming an amateur genetic genealogist, there are much better options for discovering your Y-DNA haplogroup. For instance, the National Geographic Geno 2.0 test automatically includes haplotype information in addition to your autosomal test. FTDNA also includes Y haplogroup and mtDNA haplogroup information, if you buy specific tests related to those traits. Any other companies that do DNA testing specifically for Y-DNA or mtDNA will show you your haplotype information.


If you already have taken a DNA test, you can use sites like GEDmatch to find further ancestry data. Alternatively, several of the sites below offer ancestry analysis for free. Check them out!

1. Family Tree DNA (FTDNA) — FREE

2. MyHeritage DNA — FREE

3. LivingDNA — FREE

To find out more, go to the updated list of uploading websites here!

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